DSOLV+TM Drug delivery platform

In Situ Vesicle-Forming Drug Delivery Technology

DSOLV+TM is CitraGen’s next‑generation drug delivery platform designed to overcome the toughest challenges in delivering small molecules, peptides, and biologics across biological barriers. Upon administration, DSOLV+TM formulations spontaneously form vesicle or vesicle-like supramolecular structures in situ that encapsulate and transport therapeutic agents with exceptional efficiency.

Why DSOLV+TM?


  • Enhanced Bioavailability:
    Vesicle formation at the site of administration improves transport across mucosal and epithelial barriers.

  • High Encapsulation Efficiency:
    DSOLV+TM enables efficient loading and retention of therapeutic agents, including structurally complex biologics.

  • Rapid Vesicle Formation:
    Ultra-fast hydration and dissolution deliver immediate availability of both drug and vesicle-forming components.

  • Versatile Across Modalities:
    Compatible with small molecules, peptides, proteins, nucleic acids, and emerging therapeutic classes.

How It Works?


DSOLV+TM formulations contain optimized combinations of vesicle forming-agents. Upon exposure to physiological conditions the system self-assembles into vesicle or vesicle-like structures including:

  • bilayer and unilayer vesicles

  • small unilamellar and multilamellar vesicles

  • micelles

  • lipid nanoparticles (LNPs)

  • solid lipid nanoparticles (SLNs)

  • nanostructured lipid carriers (NLCs)

  • cubosomes, hexosomes and other non-lamellar supramolecular assemblies

These structures encapsulate and protect the therapeutic agent while facilitating efficient transport.

Flexible Delivery Formats:


DSOLV+TM supports a wide range of dosage forms:

  • Oral thin films

  • Buccal & sublingual films or powders

  • Nasal powders & vesicle‑forming sprays

  • Pulmonary dry powders & nebulized solutions

  • Ocular drops, films, and semi‑solid formulations

  • Injectables (SC, IV, long-acting injectables)

  • Reconstitutable solids for vesicle-forming solutions

Applications:


  • Small molecule therapeutics

  • Peptide therapeutics

  • Biologics and oligonucleotides

  • Enzymes

  • Vitamins and Bioactive compounds

  • Dietary supplements

  • Nutraceuticals and Cosmeceuticals

  • Herbal extracts and Functional ingredients

DSOLV+TM — Transforming Drug Delivery


CitraGen is advancing DSOLV+TM across multiple therapeutic programs and partnering with innovators seeking to unlock the full potential of challenging molecules.