DSOLV+TM is CitraGen’s next‑generation drug delivery platform designed to overcome the toughest challenges in delivering small molecules, peptides, and biologics across biological barriers. Upon administration, DSOLV+TM formulations spontaneously form vesicle or vesicle-like supramolecular structures in situ that encapsulate and transport therapeutic agents with exceptional efficiency.
Why DSOLV+TM?
Enhanced Bioavailability:
Vesicle formation at the site of administration improves transport across mucosal and epithelial barriers.High Encapsulation Efficiency:
DSOLV+TM enables efficient loading and retention of therapeutic agents, including structurally complex biologics.Rapid Vesicle Formation:
Ultra-fast hydration and dissolution deliver immediate availability of both drug and vesicle-forming components.Versatile Across Modalities:
Compatible with small molecules, peptides, proteins, nucleic acids, and emerging therapeutic classes.
How It Works?
DSOLV+TM formulations contain optimized combinations of vesicle forming-agents. Upon exposure to physiological conditions the system self-assembles into vesicle or vesicle-like structures including:
bilayer and unilayer vesicles
small unilamellar and multilamellar vesicles
micelles
lipid nanoparticles (LNPs)
solid lipid nanoparticles (SLNs)
nanostructured lipid carriers (NLCs)
cubosomes, hexosomes and other non-lamellar supramolecular assemblies
These structures encapsulate and protect the therapeutic agent while facilitating efficient transport.
Flexible Delivery Formats:
DSOLV+TM supports a wide range of dosage forms:
Oral thin films
Buccal & sublingual films or powders
Nasal powders & vesicle‑forming sprays
Pulmonary dry powders & nebulized solutions
Ocular drops, films, and semi‑solid formulations
Injectables (SC, IV, long-acting injectables)
Reconstitutable solids for vesicle-forming solutions
Applications:
Small molecule therapeutics
Peptide therapeutics
Biologics and oligonucleotides
Enzymes
Vitamins and Bioactive compounds
Dietary supplements
Nutraceuticals and Cosmeceuticals
Herbal extracts and Functional ingredients
